Sereniten Plus

Anxiolytic effect reducing Mental and Physical Stress

DESCRIPTION Sereniten Plus is a combination of Lactium, L-Theanine and Vitamin D to support the HPA axis and feedback loop for stress management and cortisol regulation.
FUNCTIONS
The neurochemical and hormonal reactions to stress are regulated through the Hypothalamic-Pituitary-Adrenal axis (HPA axis) designed for acute stressors that resolve rapidly. Present day chronic, low-grade stress results in the continual release of CRH (Corticotrophin Releasing Hormone) from the hypothalamus. This chronic secretion causes dysfunction in the HPA axis, desensitizing the hypothalamic and pituitary receptors to negative feedback from adrenaline, noradrenalin and particularly, cortisol. Loss of negative feedback within the neuro-hormonal system results in a multitude of health issues. It increases the production of ADH, aldosterone, and angiotensin increasing vascular vasoconstriction and sodium retention. It increases C-reactive protein and endothelin, promot- ing atherosclerosis and inflammation. It directly increases LDL production as well as glucocorticoid and mineralcorti- coid release, further increasing cardiac risk. When the negative feedback loop within the HPA-axis is disrupted, chronic hormonal secretion becomes “normal” for that individual. In this state, they either fail to recognize they are stressed, or they may experience exaggerated emotional and physical response to every stressor including intoler- ance to noise or light, or feeling overwhelmed by simple tasks. Stress affects so many aspect of health that is becoming crucial to rebalance the HPA-axis.
Lactium, a bioactive decapeptide, alpha-1 sequence isolated from milk is effective in not only decreasing glucocor- ticoid secretion but will assist in rebalancing the HPA pathway. Lactium® works at three areas of the HPA-axis:
1) Lactium binds specifically to the BZD site of the GABA-A receptor and does NOT bind to the PBR site of the GABA-A receptor responsible for the sedating effects seen with benzodiazepines.
2) Lactium increases the sensitivity of the hypothalamus to cortisol, re-establishing receptor sensitivity feedback within the HPA-axis. It reduces the amount of CRH produced in response to stress.
3) Lactium decreases the amount of cortisol released by the adrenal glands during acute and chronic stress

Studies in humans using alpha-S1-casein hydrolysate have resulted in anxiolytic-like effects, without side effects. Results showed a significant decrease in plasma cortisol throughout the combined stress tests and stable heart rate in the treatment group but not in the placebo group. Another study showed after 30 days of treatment a reduction in stress related symptoms including digestion, cardiovascular, intellectual, emotional, and social problems.
L-Theanine is a unique amino acid derived from tea providing relaxation support without drowsiness. L-Theanine has been shown to increase alpha-wave production, an observed pattern considered to be an index of relaxation.
Vitamin D has been included for additional support in reducing inflammation and supporting immune function.

INDICATIONS
Sereniten Plus is for individuals wanting to support their response to stress and reestablish HPA-axis to stress.

Supplement Facts
1 vegetarian capsule contains:
Casein decapeptide (milk) (Lactium) 175mg

L-Theanine (Suntheanine) 50mg

Vitamin D3/Vitamine D3 100IU
Other Ingredients: hydroxypropyl methylcellulose (capsule), cellulose and silica.
Contains NO: yeast, wheat, gluten, corn, sodium, sugar, starch, artificial coloring, preservatives or flavoring.

Recommended Use:
Adults: As a dietary supplement, adults take 1 capsule daily or as recommended by a healthcare professional.

Warning:
Do NOT use if you are pregnant, nursing or allergic to milk protein. Consult a healthcare practitioner if you are taking antidepressant and/or anxilytic medications. Keep out of the reach of children.