What Is It?

PQQ (pyrroloquinoline quinone) is a novel cofactor with antioxidant and B vitamin-like activity. It is naturally present in vegetables and in the human body, including breast milk, and posseses unique neuroprotectant and cardioprotectant properties. MicroActive CoQ10 is a water-soluble, submicron particle-sized CoQ10 generated using a patented process that complexes each CoQ10 molecule with a beta-cyclodextrin molecule. CoQ10 is bound to the lipophilic end of the molecule, while the other end is hydrophilic, facilitating dispersion and transport. At the cellular surface, the complex dissociates, liberating a single CoQ10 molecule for efficient absorption. The extended 24-hour release of MicroActive® CoQ10 also allows for convenient, once-daily dosing. Clinical research indicates superior absorption compared to solubilized and crystalline CoQ10, with low inter-subject variance.

Uses For SR-CoQ10 with PQQ
Cardiovascular Health: PQQ and CoQ10 provide antioxidant and mitochondrial support through different mechanisms, providing multifunctional support for cardiovascular health. Research indicates that both PQQ and CoQ10 support heart muscle function and healthy cellular oxygen utilization. However, the mechanisms for this support differ. Studies suggest that PQQ promotes mitochondrial synthesis and function, while CoQ10 promotes energy production as a core component of cellular respiration. These actions are particularly supportive of tissues that require a lot of energy, such as the heart muscle. Furthermore, they acts as antioxidants, providing protection from free-radicals and helping to maintain the integrity of cellular membranes.

Nerve and Cognitive Health: Numerous studies have indicated that PQQ supports nerve health. Mechanistic investigations suggest that PQQ supports several signal transduction pathways that are important in maintaining mitochondrial homeostasis and oxidative metabolism. Like CoQ10, PQQ is a powerful antioxidant that supports mitochondrial function. PQQ also promotes healthy levels of nerve growth factor and supports synaptic and intracellular neuronal responses by maintaining healthy N-methyl D-aspartate (NMDA) receptor activity. The NMDA receptor is the primary conduit for excitatory glutamate neurotransmission and is regarded as an important target for maintaining neuronal health. Several studies suggest that PQQ may promote learning ability and memory. In a double-blind, placebo-controlled clinical trial conducted in 71 middle-aged individuals, PQQ supplementation over a 12 week period supported healthy cognitive performance, and a combination of PQQ and CoQ10 provided greater support than PQQ alone.

What Is The Source?
BioPQQ® pyrroloquinoline quinone disodium salt is manufactured in Japan using a patented natural fermentation process. It contains 2.7 mg sodium per capsule. MicroActive® CoQ10-cyclodextrin complex (SR-CoQ10) contains coenzyme Q10 obtained naturally from fermentation and potato starch. Hypo-allergenic plant fiber is derived from pine cellulose.
Recommendations
Pure Encapsulations recommends 2 capsules daily, in the morning, with a meal.
Are There Any Potential Side Effects Or Precautions?
If pregnant or lactating, consult your physician before taking this product. At this time, there are no known side effects or precautions. Consult your physician for more information.
Are There Any Potential Drug Interactions?
CoQ10 may react with blood thinning medications. Consult your physician for more information.

Supplement Facts
2 capsules contain:
Coenzyme Q10 100mg
—(from MicroActive® Q10-cyclodextrin complex)
BioPQQ™ 20mg
—Pyrroloquinoline Quinone Disodium Salt
Other Ingredients: potato starch, hypo-allergenic plant fiber, vegetable capsule.
Recommended Use:
Adults: As a dietary supplement, take 2 capsules per day, in the morning, with a meal.

Warning:
If you are pregnant or nursing, please consult your healthcare professional before using this product. Keep out of the reach of children.

Note:
BioPQQ™ is manufactured in Japan using a patented natural fermentation process*

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.